Also known as the convent of San Andrés del Monte, it was founded by San Pedro de Alcántara in the 16th century, where San Pedro Bautista was ordained a friar in 1568.

On these remains, in the 18th century, Charles III ordered Ventura Rodríguez to build the Alcantarine monastery that has survived to the present day. He was particularly interested in the layout of the Royal Chapel, with an octagonal floor plan and marble pilasters supporting a cornice on which rests a majestic dome with a lantern. On the altar table of the octagonal chapel of the Saint there is a marble and bronze urn with his ashes and on the main altar an image. The small cell and the works of Ventura Rodríguez and Sabatini from the second half of the 18th century stand out. In 1972 it was declared a National Historic-Artistic Monument. The convent-sanctuary houses several museums: Sacristy, Alcantarine Hall, Cloisters, Franciscan Museum of Sacred Art.